Oxidation resistant thrombomodulin analogs
AssigneeSchering Corporation
InventorsCharles B. Glaser, Michael J. Morser, David R. Light
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Abstract
Novel soluble oxidation resistant thrombomodulin analogs are produced for various therapeutic and other uses, such as in thrombotic and vascular disease therapies. These analogs exhibit the characteristic therapeutic properties of native thrombomodulin, yet they are soluble and are not inactivated after they have been exposed to oxidants. Some of the analogs disclosed are multifunctional fusion proteins having both antithrombotic activity and some additional bioactivity.
Claims3
A thrombomodulin analog peptide that retains biological activity after exposure to oxidants at a concentration and under conditions which eliminate biological activity of native thrombomodulin said peptide having the native methionine at position 388 replaced with a leucine wherein position 388 refers to the amino acids as provided in Table 1.
Dependencies are inferred from the claim text.