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US 5,256,686 AGranted
Phenylalkan(en)oic acid
AssigneeOno Pharmaceutical Co., Ltd.
InventorsMitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
Life of this patent
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Abstract
The phenylalkan(en)oic acids of the formula: ##STR1## as defined in the specification, possess an antagonistic activity on leukotriene B.sub.4.
Claims4
A phenylalkan(en)oic acid of the formula:
- ##STR201## wherein A, taken together with W and R.sup.1, is ##STR202## Y is ethylene or vinylene;
- D is:
- i) --Z--B or
- ii) ##STR203## Z is C3-11 alkylene or alkenylene B is:
- ##STR204## or Z, taken together with B, is C3-22 alkyl;
- R.sup.3 is:
- i) hydrogen,
- ii) halogen,
- iii) C1-8 alkyl, alkoxy or alkylthio or
- iv) C2-8 alkenyl, alkenyloxy or alkenylthio;
- n is 1-3;
- R.sup.4 is C1-7 alkylene;
- R.sup.5 is:
- i) C1-12 alkyl,
- ii) C2-12 alkenyl,
- iii) C5-7 cycloalkyl or
- iv) phenethyl or phenethyl wherein the ring is substituted by one C1-4 alkoxy;
- with the proviso that:
- --A--W--R.sup.1 should bind to 3- or 4-carbon in benzene ring, and non-toxic salts thereof.
16 more elements
Dependencies are inferred from the claim text.