Methods and compositions for the treatment of gastrointestinal disorders
AssigneeThe Procter & Gamble Company
InventorBarry J. Marshall
Life of this patent
Estimating the term…
Abstract
Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000 milligrams of bismuth are administered, per day, for from 3 to 56 days. A safe and effective amount of antimicrobial is administered for from 1 to 21 days. Preferred processes also include a step for performing a diagnostic test on the subject for detection of a campylobacter-like organism infection of the subject. The invention also provides compositions containing a safe and effective amount of bismuth and a safe and effective amount of antimicrobial.
Claims49
A method, for the treatment of a human or lower animal subject having an infectious upper gastrointestinal tract disorder caused or mediated by a Campylobacter pyloridis infection in said subject, comprising administering to said subject a pharmaceutically-acceptable bismuth agent and a pharmaceutically-acceptable antimicrobial agent in amounts safe and effective for combatting the Campylobacter pyloridis infection.
A method, for the treatment of a human or lower animal subject having an infectious upper gastrointestinal tract disorder caused or mediated by Campylobacter pyloridis, comprising the steps of:
- (a) performing a diagnostic test on said subject for the detection of a Campylobacter pyloridis infection of said subject;
- and upon obtaining a positive result from said diagnostic test,
- (b) combatting said Campylobacter pyloridis infection in said subject by administering to said subject a composition comprising a pharmaceutically-acceptable bismuth agent and a composition comprising a pharmaceutically-acceptable antimicrobial agent in amounts to clear said subject of symptoms of said infection.
A method, for the treatment of a human or lower animal subject having an infectious upper gastrointestinal tract disorder caused or mediated by a Campylobacter pyloridis infection in said subject, comprising administering to said subject a pharmaceutically-acceptable bismuth salt and a pharmaceutically-acceptable antimicrobial agent in amounts safe and effective for combating the Campylobacter pyloridis infection.
A method, for the treatment of a human or lower animal subject having an infectious non-ulcerative upper gastrointestinal tract disorder caused or mediated by Campylobacter pyloridis, comprising administering to said subject:
- (a) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable bismuth salt, wherein said bismuth salt is selected from the group consisting of bismuth aluminate, bismuth subcarbonate, bismuth subcitrate, bismuth citrate, tripotassium dicitrato bismuthate, bismuth subgalate, bismuth subnitrate, bismuth tartrate, bismuth subsalicylate and mixtures thereof;
- and
- (b) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable antimicrobial agent, wherein said antimicrobial agent is selected from the group consisting of gentamicin, neomycin, kanamycin, streptomycin, erythromycin, rifampin, penicillin G, penicillin V, ampicillin, amoxycillin, bacitracin, polymyxin, tetracycline, chlortetracycline, oxytetracycline, doxycyline, cephalexin, cephalothin, chloramphenicol, clindamycin, sulfonamides, nitrofurazone, nitrofurantoin, furozolidone, metronidazole, tinidazole, nimorazole, and mixtures thereof.
A method, for the treatment of a human or lower animal subject having infectious gastritis caused or mediated by Campylobacter pyloridis infection, comprising administering to said subject:
- (a) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable bismuth salt, wherein said bismuth salt is selected from the group consisting of bismuth aluminate, bismuth subcarbonate, bismuth subcitrate, bismuth citrate, tripotassium dicitrato bismuthate, bismuth subgalate, bismuth subnitrate, bismuth tartrate, bismuth subsalicylate and mixtures thereof;
- and
- (b) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable antimicrobial agent, wherein said antimicrobial agent is selected from the group consisting of gentamicin, neomycin, kanamycin, streptomycin, erythromycin, rifampin, penicillin G, penicillin V, ampicillin, amoxycillin, bacitracin, polymyxin, tetracycline, chlortetracycline, oxytetracycline, doxycyline, cephalexin, cephalothin, chloramphenicol, clindamycin, sulfonamides, nitrofurazone, nitrofurantoin, furozolidone, metronidazole, tinidazole, nimorazole, and mixtures thereof.
A method, for the treatment of a human or lower animal subject having infectious non-ulcerative dyspepsia caused or mediated by Campylobacter pyloridis, comprising administering to said subject:
- (a) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable bismuth salt, wherein said bismuth salt is selected from the group consisting of bismuth aluminate, bismuth subcarbonate, bismuth subcitrate, bismuth citrate, tripotassium dicitrato bismuthate, bismuth subgalate, bismuth subnitrate, bismuth tartrate, bismuth subsalicylate and mixtures thereof;
- and
- (b) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable antimicrobial agent, wherein said antimicrobial agent is selected from the group consisting of gentamicin, neomycin, kanamycin, streptomycin, erythromycin, rifampin, penicillin G, penicillin V, ampicillin, amoxycillin, bacitracin, polymyxin, tetracycline, chlortetracycline, oxytetracycline, doxycyline, cephalexin, cephalothin, chloramphenicol, clindamycin, sulfonamides, nitrofurazone, nitrofurantoin, furozolidone, metronidazole, tinidazole, nimorazole, and mixtures thereof.
A method, for the treatment of a human or lower animal subject having an infectious peptic ulcer disease caused or mediated by Campylobacter pyloridis, comprising administering to said subject:
- (a) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable bismuth salt, wherein said bismuth salt is selected from the group consisting of bismuth aluminate, bismuth subcarbonate, bismuth subcitrate, bismuth citrate, tripotassium dicitrato bismuthate, bismuth subgalate, bismuth subnitrate, bismuth tartrate, bismuth subsalicylate and mixtures thereof;
- and
- (b) a safe and effective amount for treating said Campylobacter pyloridis infection of a pharmaceutically-acceptable antimicrobial agent, wherein said antimicrobial agent is selected from the group consisting of gentamicin, neomycin, kanamycin, streptomycin, erythromycin, rifampin, penicillin G, penicillin V, ampicillin, amoxycillin, bacitracin, polymyxin, tetracycline, chlortetracycline, oxytetracycline, doxycyline, cephalexin, cephalothin, chloramphenicol, clindamycin, sulfonamides, nitrofurazone, nitrofurantoin, furozolidone, metronidazole, tinidazole, nimorazole, and mixtures thereof.
A method for the treatment of a human or lower animal subject having an infectious non-ulcerative upper gastrointestinal tract disorder caused or mediated by Campylobacter pyloridis, by combatting said Campylobacter pyloridis infection in said subject comprising the step of administering to said subject a composition comprising a pharmaceutically-acceptable bismuth agent and a composition comprising a pharmaceutically-acceptable antimicrobial agent in amounts to clear said subject of symptoms of said infection.
A method for the treatment of a human or lower animal subject having infectious gastritis caused or mediated by Campylobacter pyloridis, by combatting said Campylobacter pyloridis infection in said subject comprising the step of administering to said subject a composition comprising a pharmaceutically-acceptable bismuth agent and a composition comprising a pharmaceutically-acceptable antimicrobial agent in amounts to clear said subject of symptoms of said infection.
A method for the treatment of a human or lower animal subject having infectious non-ulcerative dyspepsia caused or mediated by Campylobacter pyloridis, by combatting said Campylobacter pyloridis infection in said subject comprising the step of administering to said subject a composition comprising a pharmaceutically-acceptable bismuth agent and a composition comprising a pharmaceutically-acceptable antimicrobial agent in amounts to clear said subject of symptoms of said infection.
A method for the treatment of a human or lower animal subject having infectious peptic ulcer disease caused or mediated by Campylobacter pyloridis, by combatting said Campylobacter pyloridis infection in said subject comprising the step of administering to said subject a composition comprising a pharmaceutically-acceptable bismuth agent and a composition comprising a pharmaceutically-acceptable antimicrobial agent in amounts to clear said subject of symptoms of said infection.
A method for the treatment of a human or lower animal subject having infectious duodenal ulcers caused or mediated by Campylobacter pyloridis, by combatting said Campylobacter pyloridis infection in said subject comprising the step of administering to said subject a composition comprising a pharmaceutically-acceptable bismuth agent and a composition comprising a pharmaceutically-acceptable antimicrobial agent in amounts to clear said subject of symptoms of said infection.
A method for the treatment of a human or lower animal subject having infectious gastric ulcers caused or mediated by Campylobacter pyloridis, by combatting said Campylobacter pyloridis infection in said subject comprising the step of administering to said subject a composition comprising a pharmaceutically-acceptable bismuth agent and a composition comprising a pharmaceutically-acceptable antimicrobial agent in amounts to clear said subject of symptoms of said infection.
Dependencies are inferred from the claim text.