Radiological imaging method, and contrast media reagents therefor
AssigneeBoron Biologicals, Inc.
InventorBernard F. Spielvogel
Life of this patent
Estimating the term…
Abstract
A method of imaging a corporeal situs by radiological techniques, comprising delivery to the corporeal situs of an imagingly effectively amount of a physiologically acceptable composition comprising a boron reagent. A variety of illustrative boron reagents is described, including iodinated boron salts, and boron-containing cyclophosphazene and polyphosphazene reagents having radiopaque character. The reagents and method of the present invention may be employed for a wide variety of radiological imaging applications, e.g., excretory urography, angiocardiography, and aortography.
Claims7
A cyclophosphazene of the formula:
- ##STR10## wherein:
- R.sub.1 and R.sub.2 may be the same or different, and are independently selected from hydrogen, halo, alkyl, alkoxy, haloalkyl, aryl, aryloxy, arylalkyl, alkenyl, amino, alkylamino, and arylamino groups;
- and
- n is from 3 to 8;
- with the proviso that at least one of the R.sub.1 and R.sub.2 groups comprises boroiodide functionality.
A cyclophosphazene of the formula:
- ##STR11## wherein:
- A is borohydride functionality of triiodophenyl;
- X is a divalent amino or alkoxide linker moiety;
- and
- R.sub.2 is a water solubility-imparting functional group.
A cyclophosphazene of the formula:
- ##STR12##
A cyclophosphazene of the formula:
- ##STR13## wherein G is triiodophenyl.
Dependencies are inferred from the claim text.