Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them
AssigneeElf Sanofi
InventorsUmberto Guzzi, Marco Baroni, Sergio Boveri, Luciano Manara, Alberto Bianchetti
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Abstract
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group, in optically active or inactive form as well as their acid addition salts are described. A process for their preparation and pharmaceutical compositions containing the compounds of formula (i) or their pharmaceutically acceptable acid addition salts, are also described.
Claims11
An aryloxypropanolaminotetralin compound of formula (i) and acid addition salts thereof ##STR18## wherein R is hydrogen, hydroxy or methoxy;
- and Ar represents naphthyl, tetralyl, indanyl, indenyl, phenyl or phenyl substituted by a group selected from the group consisting of halogen, cyano, hydroxy, amino, nitro, carboxyl, carbamoyl, trifluoromethyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.3-8 cycloalkyl, C.sub.1-7 alkanoyl, C.sub.1-10 alkoxy, C.sub.2-10 hydroxyalkyl, C.sub.2-10 alkoxyalkyl, C.sub.3-10 alkoxyalkoxyalkyl, C.sub.2-10 alkoxyalkoxy, C.sub.2-10 alkenyloxy, C.sub.3-10 alkenyloxyalkyl, C.sub.2-10 alkynyloxy, C.sub.3-10 alkynyloxyalkyl, C.sub.3-8 cycloalkoxy, C.sub.1-10 alkylthio, C.sub.2-10 alkylthioalkyl, C.sub.1-7 acylamino, C.sub.2-8 acylaminoalkyl, C.sub.1-6 acyloxy, C.sub.2-5 alkoxycarbonyl, C.sub.4-8 cycloalkoxycarbonyl, and aminocarbonylamino.
Dependencies are inferred from the claim text.