Preparation and use of polyethylene glycol propionaldehyde
AssigneeUniversity of Alabama in Huntsville
InventorsJ. Milton Harris, M. R. Sedaghat-Herati
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Abstract
A new polyethylene glycol derivative (PEG) having the property of not being destroyed by water and also being able to retain reactivity in water and selectively react with amine groups. Also provided is a process for modifying organic or polymer surfaces in water by connecting PEG derivatives to exposed amine groups which provides a process whereby there is efficient linking to organic or polymer surfaces in water by use of the PEG derivatives.
Claims19
A compound, as described by formula (I):
- ##STR3## wherein R.sub.1 and R.sub.3 each independently consist of an element selected from the group consisting of ##STR4## R.sub.4 --N.dbd.CH, and R.sub.4 --NH--CH.sub.2, wherein R.sub.4 is an antibody;
- and wherein X is selected from elements of the group consisting of O, and S;
- and wherein R.sub.2 is a C.sub.1 to C.sub.6 alkyl, or H, and;
- wherein n is an integer, and n less than 10,000, and m is an integer selected from the group consisting of 2, 3, 4, 5, or 6.
A process for amine modifications comprising the steps of:
- preparing an amine comprising substance in a solution and adding a compound, I, ##STR6## wherein X=O or S, n<10,000, and R.sub.2 is a C.sub.1 to C.sub.6 alkyl, or H, and m is an integer selected from an element of the group consisting of 1, 2, 3, 4, 5, or 6.
A process for amine modification, as recited in claim 11 or 12, wherein said solution is buffered and contains enough reducing agent to reduce imine bonds occurring in an intermediate product of said amine comprising and said compound.
Dependencies are inferred from the claim text.