Polymeric carriers for non-covalent drug conjugation
AssigneeNeoRx Corporation
InventorsAlton C. Morgan, Jr., David C. Anderson
Life of this patent
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Abstract
Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.
Claims18
A targeting protein/polymeric carrier/drug conjugate comprising a targeting protein covalently bound to a polymeric carrier that comprises a drug-binding domain derived from a drug-binding protein, and a drug non-covalently bound to the polymeric carrier, wherein the polymeric carrier does not comprise an entire drug-binding protein, but is derived from a drug-binding domain of said drug-binding protein, wherein the molecular weight of the polymeric carrier is less than about 60,000 daltons, and wherein said drug is an anti-cancer anthracycline antibiotic, cis-platinum, methotrexate, vinblastine, mitoxantrone, ARA-C, 6-mercaptopurine, 6-mercaptoguanosine, mitomycin C or a steroid.
A targeting protein/polymeric carrier/drug conjugate comprising a targeting protein covalently bound to a polymeric carrier, and a drug non-covalently bound to the polymeric carrier, wherein the polymeric carrier comprises from 2 to about 20 drug-binding domains derived from drug-binding protein;
- wherein the polymeric carrier does not comprise an entire drug-binding protein, but is derived from drug-binding domains of said drug-binding protein(s), and the molecular weight of the polymeric carrier is less than about 60,000 daltons.
Dependencies are inferred from the claim text.