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AssigneeChiron Corporation
InventorsRonald N. Zuckermann, Verena D. Heubner, Daniel V. Santi, Michael A. Siani
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Method and apparatus for synthesizing biopolymers, such as polypeptides and polynucleotides. The apparatus includes plural reaction vessels in which subunit coupling to biopolymers in a particle suspension is carried out. The vessels are connected to common valving structure for use in mixing the suspension and removing suspension liquid. In one embodiment, a robotic arm in the apparatus is operable to transfer reaction solution to the reaction vessels, and to transfer particle suspensions from the reaction vessels to a mixing vessel and back to the reaction vessels. The method can be used to produce preferably equi-molar amounts of different-sequence biopolymers, such as polypeptides and polynucleotides.
Apparatus for use in synthesizing different-sequence biopolymers by sequential addition of biopolymer subunits to immobilized subunits carried on solid phase particles in a particle suspension, said apparatus comprising, in operative condition,
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