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US 5,250,689 AGranted
Process for the production of 2-(methylthio)-disodium barbiturate
AssigneeLonza Ltd.
InventorsJean-Paul Roduit, Marcel Etzensperger, Alain Wellig
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Abstract
A process for the production or 2-(methylthio)-disodium barbiturate. Thiourea, malonic acid dimethyl ester and sodium methanolate are reacted to disodium thiobarbiturate. The disodium thiobarbiturate then is reacted with methyl bromide, optionally in the presence of a base, to the end product.
Claims18
Process for the production of 2-(methylthio)-disodium barbiturate of the formula:
- ##STR4## characterized in that, in the first stage, thiourea, malonic acid dimethyl ester and sodium methanolate, in methanol, are reacted to disodium thiobarbiturate and, in the second stage, the latter is reacted with methyl bromide to the end product according to formula I.
Dependencies are inferred from the claim text.