Transdermal administration method of protein or peptide drug and its administration device thereof
AssigneeKorean Research Institute on Chemical Technology
InventorsHai Bang Lee, Bung Chul Shin
Life of this patent
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Abstract
A transdermal administration method for protein or peptide drug that contacting and ionizing a protein or peptide drug immersed in hydrophilic polymer with ionizing solvent composition, and forming the drug pathway on epidermis by plural skin needles or treating the skin by a razor, and transferring the above ionized drug into the skin by electric force.
Claims19
An integration-type transdermal administration device of a patch-type which may be attached to the skin comprising the following:
- A) solvent reservoir (2) for ionizing solvent and polyelectrolyte, injected from the outside through a solvent inlet (7),
- B) drug reservoir (3) comprising drug immersed water-swellable polymer located opposite from the solvent inlet such that the solvent reservoir (2) is interposed between the drug reservoir and the inlet, with a lower portion support (5) made of non-woven fabric, including plural skin needles (4) vertically dispersed in a fixed state on said support and said support (5) is interposed between the drug reservoir and the skin needles,
- C) stacking-structural adhesive layer(6) formed around the supporter of the drug reservoir.
A separation-type transdermal administration kit of the patch-type which may be attached to the skin comprising the following:
- a) electrode (11) located uppermost and furthest from the place of skin attachment;
- b) solvent reservoir (12) for ionizing solvent and polyelectrolyte located below the electrode (11);
- c) semipermeable membrane (18) which may have a molecular weight cut off range in the range of from 200 to 20,000 which forms the lower portion of the solvent reservoir (12);
- d) drug reservoir (13) comprising a drug-immersed water swellable polymer located below the semipermeable membrane (18);
- e) patch body (30) comprising an adhesive layer (16) formed around the drug reservoir (13);
- and
- f) skin needles (14) fixed vertically in a skin needle plate (15) separated from the patch body.
A transdermal administration method for a peptide drug comprising the steps of:
- i) contacting the drug immersed in polyelectrolyte with ionizing solvent composition wherein the drug is ionized,
- ii) forming the drug pathway on the skin epidermis by penetrating a plurality of skin needles into the skin epidermis at a treatment site
- iii) transferring the ionized drug into the skin at the treatment site by iontophoretic force.
A transdermal administration method for a drug selected from the group consisting of captopril, bradykinin, atriopeptin, calcitonin gene factor, cholecystokinin (CCK-8, 32), .beta.-endorphin, nerve growth factor, melanocyte inhibitor -I, gastrin antagonist, neuro-tension, somatotatin, interferon, cyclosporin, encephalins, albumin, insulin, vasopressins, oxytocin, growth hormone, LH (Luetinizing Hormone) and TRH (Thyrotropin Releasing Hormone), comprising the steps of:
- i) contacting the drug immersed in a polyelectrolyte with an ionizing solvent composition wherein,
- the ionizing solvent contains 1 to 50% by volume of solvents selected from the group consisting of salt buffer solutions of phenol derivatives, acetic acid, hydrochloric acid, ammonia water, and caustic soda;
- and
- the polyelectrolyte contains 1 to 30% by volume of one or more polyelectrolytes selected from the group consisting of soluble or insoluble polyacrylamide, polyvinylimine, quadravalent ammonium, polyacrylate, carboxymethyl cellulose and alginate, based on 100% by volume of water;
- ii) forming the drug pathway on the skin by micro-piercing by penetrating a plurality of skin needles into the skin epidermis at a treatment site;
- and
- iii) transferring the ionized drug into the skin at the treatment site by iontophoretic force.
Dependencies are inferred from the claim text.