Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
AssigneeAmerican National Red Cross
InventorsStein Holme, William A. L. Heaton
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Abstract
The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days.
Claims14
A sterile, plasma-free red blood cell storage medium comprising:
- a physiologically compatible, aqueous electrolyte solution, one liter of said electrolyte solution having:
- between about 3.0 grams and about 25.0 grams of dextrose;
- between about 3.0 grams and about 6.0 grams of sodium citrate;
- and
- between about 2.0 grams and about 4.2 grams of sodium bicarbonate;
- said red blood cell storage medium being isotonic and having a pH in a range of between about 6.8 and about 7.4, said red blood cell storage medium being capable of preserving red blood cells for at least about 49 days at a temperature of at least about 4.degree. C.
A process for preserving red blood cells in a sterile, plasma-free red blood cell storage medium comprising:
- preparing a physiologically compatible, aqueous electrolyte solution, one liter of said electrolyte solution having:
- between about 0.26 gram and about 0.30 gram of adenine;
- between about 3.0 grams and about 25.0 grams of dextrose;
- between about 3.0 grams and about 6.0 grams of sodium citrate;
- and
- between about 2.0 grams and about 4.2 grams of sodium bicarbonate;
- suspending red blood cells in said red blood cell storage medium, said red blood cell storage medium being isotonic and having a pH in a range of between about 6.8 and about 7.4, whereby a substantial concentration of said red blood cells remain viable for at least about 49 days at a temperature of at least about 4.degree. C.
Dependencies are inferred from the claim text.