Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsMiriam Orevi, Meir Rigbi, Amiram Eldor
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Abstract
A composition of matter useful as an inhibitor of blood platelet aggregation, for the treatment of various clinical disorders such as thrombotic, inflammatory and immunological disorders. This composition of matter is derived from the saliva of leeches of the Hirudinidae family. The composition contains various components, all having molecular weights lower than 2,000 daltons. The composition has an inhibitory activity against platelet aggregation induced by various aggregating agents, including Platelet Activating Factor-acether (PAF-acether), arachidonic acid, thrombin, ADP and epinephrine.
Claims10
A composition effective as an inhibitor of blood platelet aggregation, comprising an isolated fraction derived from Hirudinidae leeches saliva, having absorbance at 260 nm twice as high as its absorbance at 280 nm, wherein active components are phospholipids, all having molecular weights lower than 2,000 daltons and having inhibitory activity against platelet aggregation induced by PAF-acether or thrombin.
Dependencies are inferred from the claim text.