US 5,244,903 AGranted

Camptothecin analogs as potent inhibitors of topoisomerase I

AssigneeResearch Triangle Institute

InventorsMonroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar

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Abstract

A method for synthesizing camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase.

Claims1

Dependent claims

A method of inhibiting the enzyme topoisomerase I in a mammal, comprising:

administering to said mammal an effective inhibitory amount of 10,11-methylenedioxy-20(S)-camptothecin free of 10,11-methylenedioxy-20(R)-camptothcin.

Dependencies are inferred from the claim text.

Facts

Application: 07/600,825Filed 22 Oct 1990 · continuation in part
Priority: 31 Mar 1987
Granted: 14 Sep 1993
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61K 31/44
Having six-membered rings with one nitrogen as the only ring hetero atom: non condensed pyridines; Hydrogenated derivatives thereof
A61K 31/47
Having six-membered rings with one nitrogen as the only ring hetero atom: quinolines; Isoquinolines
A61P 35/00
Antineoplastic agents

Family

Serial32,449Parent of this continuation-in-part · filed 31 Mar 1987
Serial38,157Parent of this continuation · filed 14 Apr 1987
Serial424,910Parent of this continuation-in-part · filed 23 Oct 1989
Serial511,953Parent of this continuation-in-part · filed 17 Apr 1990
US 5,106,742 AParent of this continuation-in-part
US 4,894,456 AParent of this continuation-in-part
US 5,244,903 AThis patent

From the US filing history. Foreign family members aren’t listed.

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