Derivatives of long chain fatty alcohols, their uses, particularly as cytotrophic and cytoprotective molecules, and pharmaceutical compositions containing them
AssigneeMedafor, Incorporated
InventorJacques Borg
Life of this patent
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Abstract
Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, conditions linked to skin ageing, the phenomena of thrombosis and atherosclerosis, and immune deficiencies.
Claims11
Derivatives of fatty alcohols, characterized by the following general formula:
- R.sub.1 --/A--(X).sub.y --B/.sub.p --R.sub.2
- in which
- p is equal to 1 or 2,
- y=0 or 1,
- A-(X).sub.y --B is a hydrocarbon chain of 11 to 50 carbon atoms, wherein said hydrocarbon chain is unsubstituted or substituted by one or more alkyl groups of 1 to 3 carbon atoms, or by one or more OR.sub.a groups, R.sub.a representing H or an alkyl group of 1 to 3 carbon atoms, in which:
- A and B, identical or different, are saturated or unsaturated aliphatic chain;
- X is a saturated or unsaturated hydrocarbon chain
- R.sub.1 and R.sub.2, identical or different, represent:
- a group of formula (A):
- ##STR58## containing a single or a double bond and being unsubstituted or substituted by one or more --CH.sub.3 and/or --OH and/or --OR groups, R being defined below, and/or an oxy (=0) group,
- a --OR group, in which R represents a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, or a ##STR59## group, in which R' represents a hydrogen atom or an alkyl group of 1 to 5 carbon atoms, provided that at least one of the pair of R.sub.1 and R.sub.2 represent a group of the formula (A).
A derivative characterized by the formula:
- ##STR61##
A derivative characterized by the formula:
- ##STR62##
A derivative characterized by the formula:
- ##STR63##
A derivative having the following formula:
- ##STR64##
A derivative having the following formula:
- ##STR65##
A derivative having the following forumla:
- ##STR66##
Dependencies are inferred from the claim text.