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AssigneeThe Regents of the University of California
InventorsChristopher J. Murphy, Ted W. Reid, Mark J. Mannis, Bradley A. Foster, James S. Cullor, Michael E. Selsted, Robert I. Lehrer, Tomas Ganz
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A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a natural, synthetic, or analog defensin molecule having both a mitogenic activity capable of stimulating cell growth and an antimicrobial activity capable of inhibiting the growth of a wide variety of pathogens. In addition to therapeutic use, the defensins are useful as mitogens in cell and tissue culture media.
A method for treating wounds in mammalian tissue to promote healing, said method comprising applying a defensin peptide to the wound in an amount sufficient to promote healing of the wound.
A method for treating corneal wounds and keratitis, said method comprising applying a defensin peptide to the eye of an affected host in an amount sufficient to effect said treating.
Dependencies are inferred from the claim text.