Process for the preparation of 4-amino-unsaturated androstanedione derivatives
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsFabrizio Orzi, Antonio Longo, Matteo D'Anello, Natale Barbugian
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Abstract
4-amino-unsaturated androstanedione derivatives provided with aromatase inhibitory activity are obtained by hydrolyzation of a corresponding compound of formula II ##STR1##
Claims6
A process for the preparation of 4-amino androstanedione derivatives having the following formula (I), and the pharmaceutically acceptable salts thereof, ##STR7## wherein one of R.sub.1 and R.sub.2 is hydrogen and the other is hydrogen or C.sub.1 -C.sub.6 alkyl, the process comprising hydrolysing a compound of formula (II) ##STR8## wherein R.sub.1 and R.sub.2 are as defined above and optionally salifying a compound of formula (I) or obtaining a free compound of formula (I) from a salt thereof.
A compound of formula (II) ##STR12## wherein one of R.sub.1 and R.sub.2 is hydrogen and the other is hydrogen or C.sub.1 -C.sub.6 alkyl.
A compound of formula (III) ##STR13## wherein one of R.sub.1 and R.sub.2 is hydrogen and the other is hydrogen or C.sub.1 -C.sub.6 alkyl.
Dependencies are inferred from the claim text.