Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
AssigneeSanofi
InventorsXavier Emonds-Ai, Pierre Goulaouic, Vincenzo Proietto, Didier Van Broeck
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AssigneeSanofi
InventorsXavier Emonds-Ai, Pierre Goulaouic, Vincenzo Proietto, Didier Van Broeck
Estimating the term…
The invention relates to compounds of formula: ##STR1## in which Y represents--either a group Cy--N in which Cy represents a phenyl, optionally substituted; a C.sub.3 -C.sub.7 cycloalkyl group; a pyrimidinyl group or a pyridyl group; or a group ##STR2## in which Ar represents a phenyl, optionally substituted, a pyridyl group; a thienyl group; x is zero or one; X represents a hydroxyl, a C.sub.1 -C.sub.4 alkoxy; a hydroxyalkyl; a C.sub.1 -C.sub.4 acyloxy; a phenacyloxy; a carboxyl; a C.sub.1 -C.sub.4 carbalkoxy; a cyano; an aminoalkylene; a group --N--(X.sub.1).sub.2 in which the groups X.sub.1 independently represent hydrogen, a C.sub.1 -C.sub.4 alkyl; a group ##STR3## in which Alk represents a C.sub.1 -C.sub.6 alkyl; a group ##STR4## in which the Alk.sub.1 is a C.sub.1 -C.sub.3 alkylene and Alk'.sub.1 is a C.sub.1 -C.sub.3 alkyl; a C.sub.1 -C.sub.4 acyl; a group --S--X.sub.2 in which X.sub.2 represents hydrogen or a C.sub.1 -C.sub.4 alkyl group; or alternatively X forms a double bond with the carbon atom to which it is linked and with the adjacent carbon atom in the heterocycle; m is 2 or 3; Ar' represents a phenyl, optionally substituted; a thienyl; a benzothienyl; a naphthyl; an indolyl; an indolyl N-substituted with a C.sub.1 -C.sub.3 alkyl; R represents hydrogen, a C.sub.1 -C.sub.4 alkyl; T represents a group selected from --C(O)-- and --C(W)--NH-- W being an oxygen or sulphur atom, and Z represents either hydrogen, or M or OM when T represents a --C(O)-- group, or M when T represents a group--C(W)--NH; M represents a C.sub.1 -C.sub.6 alkyl; a phenylalkyl, a pyridyl alkyl; a naphthylalkyl; a pyridylthioalkyl; a styryl; or one of its salts with inorganic or organic acids.
Compound of formula:
A method for treatment of neurogenic inflammation of the respiratory tract as recited in claim 18, wherein said therapeutic amount is about 0.25 to 100 mg per day of said compound according to formula (I).
Dependencies are inferred from the claim text.