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US 5,236,714 AGranted
Abusable substance dosage form having reduced abuse potential
AssigneeAlza Corporation
InventorsEun S. Lee, Victor Goetz
Life of this patent
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AssigneeAlza Corporation
InventorsEun S. Lee, Victor Goetz
Estimating the term…
Compositions and dosage forms for administering abusable substances are disclosed which have a reduced potential for abuse without diminishing the therapeutic or beneficial effects of the abusable substance. Topical compositions for application to the skin or mucosa contain the abusable substance in a form which is permeable to the skin or mucosa to which it is to be applied and an antagonist for the abusable substance is present in the composition in an abuse negating amount and in a form that is impermeable to the skin or mucosa to which the composition is to be applied. Controlled release dosage forms which release the abusable substance from a drug reservoir composition confined behind a release rate controlling barrier have the abusable substance and its antagonist in the drug reservoir. The abusable substance is present in a form that is releasable from the dosage form and the antagonist is present in an abuse negating amount in a form that is not releasable from the dosage form. Thus the compositions and dosage forms of this invention permit the therapeutic use, at substantially full potency, of an abusable substance when use as prescribed but reduce the abuse potential of the compositions and dosage forms by other routes of administration. Preferred embodiments of the invention utilize fentanyl as the abusable substance and naltrexone as the antagonist in a transdermal dosage form.
A method for administering an abusable substance to the skin or mucosa to produce a predetermined beneficial effect which comprises:
A method for administering an abusable substance to the body from a dosage form having a reduced potential for abuse comprising:
A composition of matter for the administration of an abusable substance by application of the composition to the skin or mucosa, said composition having a reduced potential for abuse and comprising a mixture of:
A dosage form for administering an abusable substance to the body, said dosage form having a reduced potential for abuse and comprising, in combination:
A dosage form for the administration of an abusable substance through the skin or mucosa, said dosage form having a reduced potential for abuse and comprising:
A method for administering an abusable substance selected from the group consisting of fentanyl, sufentanil, carfentanil, lofentanil, alfentanil, hydromorphone, oxycodone, propoxyphene, pentazocine, methadone, tilidine, butorphanol, buprenorphine, levorphanol, codeine, oxymorphone, meperidine, dihydrocodeinone and cocaine to the skin or mucosa to produce a predetermined beneficial effect which comprises:
A method for administering an abusable substance selected from the group consisting of fentanyl, sufentanil, carfentanil, lofentanil, alfentanil, hydromorphone, exycodone, propoxyphene, pentazocine, methadone, tilidine, butorphanol, buprenorphine, levorphanol, codeine, oxymorphone, meperidine, dihydrocodeinone and cocaine to the body from a dosage form having a reduced potential for abuse comprising:
A composition of matter for the administration of an abusable substance selected from the group consisting of fentanyl, sufentanil, carfentanil, lofentanil, alfentanil, hydromorphone, oxycodone, propoxyphene, pentazocine, methadone, tilidine, butorphanol, buprenorphine, levorphanol, codeine, oxymorphone, meperidine, dihydrocodeinone and cocaine by application of the composition to the skin or mucosa, said composition having a reduced potential for abuse and comprising a mixture of:
A dosage form for administering an abusable substance selected from the group consisting of fentanyl, sufentanil, carfentanil, lofentanil, alfentanil, hydromorphone, oxycodone, propoxyphene, pentazocine, methadone, tilidine, butorphanol, buprenorphine, levorphanol, codeine, oxymorphone, meperidine, dihydrocodeinone and cocaine to the body, said dosage form having a reduced potential for abuse and comprising, in combination:
A dosage form for the administration of an abusable substance selected from the group consisting of fentanyl, sufentanil, carfentanil, lofentanil, alfentanil, hydromorphone, oxycodone, propoxyphene, pentazocine, methadone, tilidine, butorphanol, buprenorphine, levorphanol, codeine, oxymorphone, meperidine, dihydrocodeinone and cocaine through the skin or mucosa, said dosage form having a reduced potential for abuse and comprising:
A dosage form for the administration of fentanyl through the skin or mucosa, said dosage form having a reduced potential for abuse, comprising, in combination:
Dependencies are inferred from the claim text.