US 5,235,033 A · Alpha-morpholino ribonucleoside derivatives and polymers thereof

Abstract

Alpha-morpholino subunits and polymer compositions composed of alpha-morpholino subunits are disclosed. These subunits can be linked together by uncharged linkages, one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide. The polymers of the present invention can be used in place of standard RNA or DNA oligomers for a number of standard laboratory procedures, for example, as probes in solid-phase systems and nucleic acid hybridization analyses. Further, the polymers of the present invention have potential use as therapeutic agents in anti-sense-type technologies.

Claims16

Dependent claims

A polymer composition comprised of .alpha.-morpholino subunit structures of the form:

##STR2## where (i) the structures are linked together by uncharged linkages, one to three atoms long, joining the morpholino nitrogen of one subunit to the 5', exocyclic carbon of an adjacent subunit, and (ii) P.sub.i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.

Dependencies are inferred from the claim text.

Facts

Application

07/454,056Filed 20 Dec 1989 · continuation in part

Priority

15 Mar 1985

Granted

10 Aug 1993

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07H 21/00
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate
A61K 47/545
The modifying agent being an organic compound: heterocyclic compounds
A61K 47/59
The modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule: obtained otherwise than by…
C07K 14/003
By chemical synthesis: peptide-nucleic acids

Family

Serial712,396Parent of this continuation-in-part · filed 15 Mar 1985

Serial911,258Parent of this continuation-in-part · filed 24 Sep 1986

Serial944,707Parent of this continuation-in-part · filed 8 Dec 1986

Serial100,033Parent of this continuation-in-part · filed 23 Sep 1987

US 5,142,047 AParent of this continuation-in-part

US 5,235,033 AThis patent

From the US filing history. Foreign family members aren’t listed.

Alpha-morpholino ribonucleoside derivatives and polymers thereof

Life of this patent

Alpha-morpholino ribonucleoside derivatives and polymers thereof

Life of this patent

Abstract

Claims16