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US 5,234,957 AGranted
Compositions and methods for topical administration of pharmaceutically active agents
AssigneeNoven Pharmaceuticals, Inc.
InventorJuan A. Mantelle
Life of this patent
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Abstract
A composition for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a flexible, finite, pharmaceutically acceptable, bioadhesive carrier, and a solvent for the pharmaceutical agent(s) in the carrier and a method of administering the pharmaceutical agent to a mammal are disclosed.
Claims23
A composition for topical application comprising:
- a. a therapeutically effective amount of at least one local anesthetic;
- b. a pharmaceutically acceptable solvent for the anesthetic, in an amount from about 5 to about 70 weight percent based on the weight of the whole composition;
- c. in admixture with the anesthetic agent in the solvent, a flexible, finite, pharmaceutically acceptable polysaccharide bioadhesive carrier in an amount from about 20 to about 50 weight percent based on the weight of the whole composition;
- wherein said composition contains less than 10% by weight water, is substantially water insoluble and is a bioadhesive.
1 more element
A composition for topical application comprising:
- a. a therapeutically effective amount of a first local anesthetic agent in base form;
- b. a therapeutically effective amount of a different, second local anesthetic agent in acid-addition salt form;
- c. a solvent for the first and second local anesthetic agents in an amount from about 5 to about 70 weight percent based on the weight of the whole composition;
- and
- d. in an admixture with the anesthetic agents in the solvent, a flexible, finite, pharmaceutically acceptable, bioadhesive carrier in an amount from about 20 to about 50 weight percent based on the weight of the whole composition;
- wherein the composition is substantially free of water and is substantially water insoluble.
3 more elements
Dependencies are inferred from the claim text.