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US 5,234,586 AGranted
On-line product identification in a chromatography effluent by subtraction
AssigneePerSeptive Biosystems, Inc.
InventorsNoubar B. Afeyan, Fred E. Regnier
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Abstract
Disclosed is a method and apparatus for the rapid identification of a solute of interest in an effluent stream. The method involves separation of the solutes in the effluent and identification of a particular solute of interest by its selective subtraction from the effluent stream.
Claims13
An apparatus for identifying a preselected subset of individual solutes from a liquid feed which includes a plurality of solutes, comprising:
- means for interacting differentially with said plurality of solutes in said liquid feed to produce a first stream rich sequentially in individual solutes;
- first detector means for providing a first output indicative of the temporal presence of said individual solutes in said first stream;
- means for extracting from said first stream said preselected subset of said individual solutes, said means comprising a solute specific affinity chromatography sorbent, to produce a second stream rich sequentially in remaining individual solutes;
- second detector means for providing a second output indicative of the temporal presence in said second stream of said remaining individual solutes;
- and
- comparator means which compares said first output and said second output and which identifies the presence and location of said preselected subset of said individual solutes in said first stream.
3 more elements
Dependencies are inferred from the claim text.