Process for producing individually dosed administration forms
AssigneeCapsoid Pharma GmbH
InventorsHeinrich Pins, Christiane Schmitz
Life of this patent
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Abstract
Process for producing individually dosed administration forms, in which a carrier material containing active substances plastic at elevated temperature, together with conventional additives is applied to a stationary or moving substrate or introduced into blisters or cavities produced from films and as a result the formulation material is brought into an administration form and a formulation material with a softening point range above the body temperature is heated to above the latter and is dosed under pressure with a viscosity of more than 3,000 mPa.s, together with administration forms obtainable by said process. They can be obtained simply, economically and with good quality.
Claims25
In a process for producing individually dosed administration forms in which a formulation material containing conventional additives and active substances, which is plastic at elevated temperature and which is based on a sol/gel ratio with a softening range above 37.degree. C. is heated to above 37.degree. C. and under pressure is brought into contact with a substrate and then cooled, the formulation material thereby being in a form suitable for administration, the improvement comprising transferring a warm formulation material which has a viscosity of more than 3,000 mPa.s to be dosed from a heating tank into a heated dosing apparatus which operates at high pressure, providing said heated dosing apparatus with compressed air valves which provide opening and closing cycles within the time of milliseconds, building up a uniform high pressure against said valves by pressure generating means, and discharging through a time-precisely limited opening of the valves, a constant quantity of the warm formulation material being thereby dosed onto the substrate, wherein in said discharge step the same amount of material is discharged under constant pressure each time and the valve opening times is a function of the pressure upstream of said valves.
In a process for producing individually dosed administration forms in which a formulation material containing conventional additives and active substances, which is plastic at elevated temperature and which is based on a sol/gel ratio with a softening range above 37.degree. C. is heated to above 37.degree. C. and under pressure is introduced into blisters or cavities produced from films and then cooled, the formulation material thereby being in a form suitable for administration, the improvement comprising transferring a warm formulation material which has a viscosity of more than 3000 mPa.s to be dosed from a heating tank into a heated dosing apparatus which operates at high pressure, providing said heated dosing apparatus with compressed air valves which provide opening and closing cycles within the time of milliseconds, building up a uniform high pressure against said valves by pressure generating means, and discharging through a time-precisely limited opening of the valves, a constant quantity of the warm formulation material being thereby dosed into the blisters or cavities produced from films, wherein in said discharge step the same amount of material is discharged under constant pressure each time and the valve opening times are a function of the pressure upstream of said valves.
Dependencies are inferred from the claim text.