Method of inhibiting picornavirus disease
AssigneeWiscosnin Alumni Research Foundation
InventorsAnn C. Palmenberg, Gregory M. Duke, Jorge E. Osorio
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Abstract
A method for inhibiting picornavirus disease in non-murine mammals is disclosed. A vaccine containing a live, recombinant, attenuated picornavirus with a shortened poly(C) tract is administered to the mammal. Preferably, the picornavirus in the vaccine is of the same genus as the disease-causing picornavirus and has a shortened poly(C) tract. The administration of the vaccine causes antibodies effective against the disease-causing picornavirus to be formed in vivo. In one embodiment of the invention, a vaccine containing Mengovirus with a shortened poly(C) tract can be used as a vaccine for both pigs and monkeys.
Claims9
A method of inhibiting disease caused by a cardiovirus in a live, non-murine mammal, where the disease is caused by a cardiovirus having a non-coding poly(C) tract of at least fifty nucleotides, a method comprising:
- administering to the non-murine mammal an effective amount of a vaccine which contains a live, recombinant cardiovirus that has a shortened poly(C) nucleotide tract, antibodies against the disease-causing cardiovirus are formed in vivo in the mammal and the disease is thereby inhibited;
- wherein the non-murine mammal is an animal selected from the group consisting of primates and swine and wherein the non-murine mammal is a host for said disease causing cardiovirus.
Dependencies are inferred from the claim text.