Synthetic amphiphilic glycoconjugates for neurological use
AssigneeFarmhispania S.A.
InventorsEdoardo Butelman, Cesare Sirtori
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Abstract
Chemically and sterically pure synthetic amphiphilic glycoconjugates for neurological use of the formula (I): ##STR1## in which: the saccharide ring represents a monosaccharide such as glucose, galactose or mannose; X represents O or NH and, when X represents O, R is a choline radical whereas, when X represents NH, R is an amino acid or peptide radical; R' represents a saturated or unsaturated linear or branched C.sub.8 -C.sub.18 aliphatic chain, or a ##STR2## group where m is between 7 and 17 and; n is a whole number from 1 to 5.
Claims11
Chemically and sterically pure synthetic amphiphilic glycoconjugates of the formula (I):
- ##STR16## in which:
- the saccharide ring represents a monosaccharide;
- X represents O or NH and, when X represents O, R is a choline radical whereas, when X represents NH, R is an amino acid or peptide radical selected from the group consisting of glycine, glutamic acid, Me-D-aspartate, L-pyroglutamyl-L-histidyl-L-proline, .gamma.-amino-.beta.-hydroxy butyric acid, hydroxytryptophan, Melanocyte Stimulating Hormone/Adrenocorticotropic Hormone, Adrenocorticotropic Hormone, 1-desamino-8-D-arginine-vasopressin and S-adenosyl-methionine;
- R' represents functional group selected from the group consisting of a saturated, linear C.sub.8 -C.sub.18 aliphatic chain, an unsaturated linear C.sub.8 -C.sub.18 aliphatic chain, branched C.sub.8 -C.sub.18 aliphatic chain, a ##STR17## group where m is between 7 and 17;
- and n is a whole number from 1 to 5.
Dependencies are inferred from the claim text.