1,2,4-trioxane compounds having antimalarial activity

An anti-malarial 1,2,4-trioxane of the formula:

• ##STR30## and the enantiomers thereof, wherein:
• R.sup.1 is lower alkoxy, aryloxy or aralkoxy;
• R.sup.2 is lower alkyl, hydroxy substituted-lower alkyl or ester or ether derivatives of such hydroxy substituted-lower alkyl;
• R.sup.3 is --(CH.sub.2).sub.m Q where Q is halogen or --OR.sup.5 where
• R.sup.5 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, aralkyl or heteroaralkyl, or
• R.sup.5 is ##STR31## where Y is C, S or P,
• Z is O or S,
• R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, lower alkoxy, aryloxy, aryl, aralkyl, mono- or di-lower alkylamino or mono- or di-arylamino;
• n is 1 or 2;
• y is 1 or 2;
• and
• m is 1, 2, 3 or 4;
• and
• R.sup.4 is hydrogen or one or two lower alkyl.