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US 5,223,516 AGranted
3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
AssigneeE. R. Squibb & Sons, Inc.
InventorsNorma G. Delaney, George C. Rovnyak, Melanie J. Loots
Life of this patent
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Abstract
Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
Claims7
A compound of the formula ##STR52## including all enantiomeric and diasteromeric forms thereof wherein:
- R.sub.3 is hydrogen or ##STR53## X is ##STR54## n is zero, one, or two;
- R.sub.5 is lower alkyl, ##STR55## R.sub.4 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, hydroxy, CF.sub.3, phenyl, ##STR56## q is zero or an integer from 1 to 7.
A compound of the formula;
- ##STR61## including all enantiomeric and disastereomeric forms thereof wherein R.sub.3 is hydrogen or ##STR62## and X is ##STR63##
Dependencies are inferred from the claim text.