Back to results
US 5,221,740 AGranted
Oxepane isomers of rapamycin useful as immunosuppressive agents
AssigneeAmerican Home Products Corporation
InventorPhilip F. Hughes
Life of this patent
Estimating the term…
Abstract
A derivative of rapamycin of general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, acyl, sulfonyl or alkyl or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.
Claims5
A compound of formula (I) ##STR5## wherein R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, alkanoyl, sulfonyl or alkyl containing 1 to 6 carbon atoms or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.