Imidazole derivatives
AssigneeGlaxo Group Limited
InventorsJohn W. Clitherow, Eric W. Collington
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Abstract
The invention relates to salts formed between basic H.sub.2 -receptor antagonists and a complex of zinc with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, and to solvates of such salts, excluding salts in which the basic H.sub.2 -receptor antagonist is ranitidine. Examples of basic H.sub.2 -receptor antagonists are cimetidine, famotidine, nizatidine and roxatidine. The salts are useful in the treatment of gastrointestinal disorders, such as peptic ulcer disease and non-ulcer dyspepsia.
Claims6
A salt formed between cimetidine and a complex of zinc with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, or a solvate of such a salt, wherein said complex of zinc and said carboxylic acid is a 1:1 complex.
The cimetidine zinc citrate complex which is N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]gua nidine2-hydroxy- 1,2,3-propanetricarboxylate zinc (2+) complex and solvates thereof wherein the ratio of zinc to citrate in said complex is 1:1.
Dependencies are inferred from the claim text.