Cyclcic FR-900520 microbial biotransformation agent
AssigneeMerck & Co., Inc.
InventorsShieh-Shung T. Chen, Raymond F. White, Georgette Dezeny, Brian R. Petuch, George M. Garrity, Byron H. Arison, Amy M. Bernick
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Abstract
Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6963) ATCC No. 55230. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
Claims1
A biologically pure culture of (MA6963), ATCC No. 55230 Streptomyces lavendulae.
Dependencies are inferred from the claim text.