Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids

A compound of the formula ##STR10## wherein R.sub.1 is selected from

• (1) hydrogen;
• (2) --NR.sub.2 R.sub.3, --OR.sub.2 or --SR.sub.2 where R.sub.2 and R.sub.3 are independently selected from
• hydrogen,
• alkyl of from one to twelve carbon atoms,
• aryl, selected from phenyl and 1- or 2-naphthyl,
• alkylaryl wherein the alkyl portion is as defined above;
• (3) C.sub.1 -C.sub.8 alkyl;
• (4) C.sub.2 -C.sub.8 alkenyl;
• (5) aralkyl wherein the aryl and alkyl portions are as defined above;
• (6) cycloalkyl of from three to eight carbon atoms;
• and
• (7) a group selected from (3)-(6) above substituted with one group selected from
• C.sub.1 -C.sub.6 alkoxy,
• halo,
• cyano,
• amino,
• carboxy,
• --COX,
• --OCOX, and
• --NHCOX
• where X is selected from
• alkoxy of from one to four carbon atoms,
• amino,
• alkylamino, dialkylamino, alkyl and aryl wherein alkyl at each occurence is of from one to twelve carbon atoms, and aryl is selected from phenyl and 1- or 2 naphthyl;
• Y is selected from sulfur and oxygen;
• n is an integer selected from 0 and 1;
• M is hydrogen or a phramaceutically acceptable cation;
• Z is a residue of a non-steroidal antiinflammatory drug of the general formula Z--COOH selected from the group consisting of
• benzofenac,
• bucloxic acid,
• butibufen,
• cicloprofen,
• cinmetacin,
• clinidacac,
• diclofenac,
• fenbufen,
• fenclofenac,
• fenoprofen,
• ibufenac,
• ibuprofen,
• keotprofen,
• naproxen, and
• sulindac,
• or a pharmaceutically acceptable salt thereof.