Soluble melanin
AssigneeYale University
InventorsJohn M. Pawelek, Seth J. Orlow
Life of this patent
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AssigneeYale University
InventorsJohn M. Pawelek, Seth J. Orlow
Estimating the term…
A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair.
A method of producing soluble melanin comprising in an aqueous reaction medium polymerizing [5,6-dihydroxyindole-2-carboxylic acid] a dihydroxyindole-carboxylic acid in the presence of oxygen.
Dependencies are inferred from the claim text.