Nisin compositions for use as enhanced, broad range bactericides
AssigneeApplied Microbiology, Inc.
InventorsPeter Blackburn, June Polak, Sara-Ann Gusik, Stephen D. Rubino
Life of this patent
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Abstract
Bacteriocin compositions comprising lanthionine containing bacteriocins and non-bactericidal agents. When the bacteriocin compositions are combined with a suitable carrier with each component present in sufficient quantities such that the composition is effective against Gram negative bacteria in addition to Gram positive bacteria, they become enhanced, rapid acting, broad range bactericides suitable for a variety of applications.
Claims44
A method of synergistically enhancing the bactericidal activity of a lanthionine-containing bacteriocin against gram positive bacteria comprising combining the lanthionine-containing bacteriocin with a suitable chelator.
A method of imparting bactericidal activity against gram negative bacteria to a lanthionine-containing bacteriocin comprising combining the lanthionine-containing bacteriocin with a suitable chelator.
A method of inhibiting the growth of or killing gram negative bacteria comprising simultaneously contacting the bacteria with a suitable amount of a lanthionine-containing bacteriocin and a suitable chelator.
A method of synergistically inhibiting the growth of or killing gram positive bacteria comprising simultaneously contacting the bacteria with a suitable amount of a lanthionine-containing bacteriocin and a suitable chelator.
A method of inhibiting the growth of or killing gram negative and gram positive bacteria which comprises contacting the bacteria with a bactericidal composition comprising an effective amount of a lanthionine-containing bacteriocin, a suitable chelator and a suitable carrier.
A method of inhibiting the growth of or killing gram negative bacteria with a lanthionine-containing bacteriocin which comprises contacting the bacteria simultaneously with an effective amount of nisin and an effective amount of a suitable chelator.
A method of preventing contamination of food products by gram negative bacteria which comprises applying to a food product a lanthionine-containing-bacteriocin composition comprising an effective amount of a lanthionine-containing bacteriocin and an effective amount of a chelator.
A method of preventing contamination of food products by gram negative bacteria and more effectively preventing contamination of food products by gram positive bacteria which comprises applying to a food product a lanthionine-containing-bacteriocin composition comprising an effective amount of a lanthionine-containing bacteriocin and an effective amount of a chelator.
A method for preventing or treating infections caused by gram negative or gram positive bacteria which comprises applying to a wound, burn or surgical incision a lanthionine-containing-bacteriocin composition comprising an effective amount of lanthionine-containing bacteriocin and an effective amount of a chelator.
A method for preventing or treating conditions caused by gram negative or gram positive bacteria on the skin which comprises applying to the affected skin a lanthionine-containing-bacteriocin composition comprising an effective amount of lanthionine-containing bacteriocin and an effective amount of a chelator.
A method for preventing or treating conditions caused by gram negative or gram positive bacteria on mucosal epithelia which comprises applying to the affected tissue a lanthionine-containing-bacteriocin composition comprising an effective amount of lanthionine-containing bacteriocin and an effective amount of a chelator.
A method of sanitizing hard surfaces against gram negative or gram positive bacteria which comprises applying to a hard surface a lanthionine-containing-bacteriocin composition comprising an effective amount of a lanthionine-containing-bacteriocin and an effective amount of a chelator.
A method of inhibiting the growth of or killing Salmonella typhimurium which comprises contacting the bacteria with an effective amount of a composition comprising the lanthionine-containing-bacteriocin nisin and a suitable chelator.
A method of inhibiting the growth of or killing Escherichia coli which comprises contacting the bacteria with an effective amount of a composition comprising the lanthionine-containing-bacteriocin nisin and a suitable chelator.
A method of inhibiting the growth of or killing Pseudomonas aeruginosa which comprises contacting the bacteria with an effective amount of a composition comprising the lanthionine-containing-bacteriocin nisin and a suitable chelator.
A method of inhibiting the growth of or killing Bacteroides gingivalis which comprises contacting the bacteria with an effective amount of a composition comprising the lanthionine-containing-bacteriocin nisin and a suitable chelator.
A method of inhibiting the growth of or killing Actinobacillus actinomycetescomitans which comprises contacting the bacteria with an effective amount of a composition comprising the lanthionine-containing-bacteriocin nisin and a suitable chelator.
A method of inhibiting the growth of or killing Klebsiella pneumoniae which comprises contacting the bacteria with an effective amount of a composition comprising the lanthionine-containing-bacteriocin nisin and a suitable chelator.
Dependencies are inferred from the claim text.