System and method for processing biological fluid
AssigneePall Corporation
InventorsDavid B. Pall, Thomas C. Gsell, Vlado I. Matkovich, Thomas Bormann
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Abstract
A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
Claims32
A method for processing a biological fluid comprising:
- expressing a biological fluid from a first container to a first porous medium comprising a red cell barrier medium;
- and
- expressing a biological fluid from the first container to a second porous medium.
A method for processing whole blood comprising:
- centrifuging whole blood;
- expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium;
- and
- expressing a sediment layer of the centrifuged blood through a second porous medium comprising a leucocyte depletion medium.
A method for processing whole blood comprising:
- centrifuging whole blood;
- expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium and a leucocyte depletion medium;
- and
- expressing a sediment layer of the centrifuged blood through a second porous medium comprising a leucocyte depletion medium.
A method for processing whole blood comprising:
- centrifuging whole blood;
- expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium until the red cell barrier medium is blocked;
- and then,
- passing the supernatant layer through a separation medium.
The method of claim 21 wherein passing the supernatant layer through a separation medium comprises separating the supernatant layer into one or more components.
The method of claim 22 further comprising collecting the one or more components of the supernatant layer in at least one container.
A biological fluid processing system comprising:
- a first container;
- a first porous medium comprising a red cell barrier medium communicating with the first container, and defining a first flow path;
- and
- a second porous medium comprising a leucocyte depletion medium communicating with the first container, and defining a second flow path.
A biological fluid processing system comprising:
- a first container;
- a first porous medium comprising a red cell barrier medium communicating with the first container and defining a first flow path;
- a second container downstream of, and communicating with, the first container and defining a second flow path.
A biological fluid processing system comprising:
- a first container;
- a first porous medium comprising a red cell barrier medium communicating with the first container;
- and
- a second porous medium comprising a leucocyte depletion medium communicating with the first container independently of the first porous medium.
A biological fluid processing system comprising:
- a first container;
- a first porous medium comprising a porous red cell barrier medium having a CWST of greater than about 70 dynes/cm communicating with the first container;
- and
- a second porous medium comprising a porous leucocyte depletion medium having a CWST of greater than about 53 dynes/cm communicating with the first container.
A biological fluid processing system comprising:
- a first container;
- a first porous medium comprising a red cell barrier medium and a leucocyte depletion medium communicating with the first container, and defining a first flow path;
- and
- a second porous medium comprising a leucocyte depletion medium communicating with the first container, and defining a second flow path.
A biological fluid processing system comprising:
- a first container;
- a first porous medium comprising a red cell barrier medium communicating with the first container;
- and
- a separation medium downstream of, and communicating with, the first porous medium.
A biological fluid processing system comprising:
- a first container;
- a first porous medium comprising a red cell barrier medium communicating with the first container;
- a second porous medium comprising a leucocyte depletion medium communicating with the first container independently of the first porous medium;
- a third container communicating with the second porous medium;
- a second container communicating with the first porous medium;
- and,
- a fourth container communicating with the second container.
Dependencies are inferred from the claim text.