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US 5,217,427 AGranted
Centrifuge assembly
AssigneeBaxter International Inc.
InventorHerbert M. Cullis
Life of this patent
Estimating the term…
Abstract
A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
Claims50
A centrifuge assembly comprising:
- rotor;
- means defining a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component;
- said processing channel including one portion for performing a separation function and another portion for performing another separation function;
- said other portion of said channel being generally spiral-like relative to the true center of said rotor;
- and
- said processing channel having a total arc not greater than 360.degree..
3 more elements
A centrifuge assembly comprising:
- a rotor;
- means defining a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component;
- said channel including one portion for performing a separation function and another portion for performing another separation function;
- said other portion of said channel being generally spiral-like relative to the true center of said rotor;
- and
- fluid connection means at separated locations of said channel for introducing the suspension into and for extracting at least one suspension component from said channel, said fluid connection means including:
- a first fluid connection means;
- (a) communicating with said other, spiral-like portion of said channel,
- (b) being adapted for extracting a suspension component from said other, spiral-like portion of said channel, and
- (c) being located at a greater radial distance from the true center of the rotor than the radial distance where the suspension component enters said other, spiral-like portion of said channel.
7 more elements
A centrifuge assembly comprising:
- a rotor;
- means providing a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component;
- said channel including one portion for performing a separation function and another portion for performing another separation function;
- said other portion of said channel being generally spiral-like relative to the true center of said rotor;
- said multi-portion processing channel having a total arc not greater than 360.degree.;
- fluid connection means at separated locations along said channel for introducing the suspension and for extracting at least one suspension component from said channel;
- one of said fluid connection means for extracting a suspension component (a) communicating with said other, spiral-like portion of the channel and (b) being adapted for extracting a suspension component from the other, spiral-like portion.
4 more elements
A centrifuge assembly comprising:
- a rotor;
- a generally annularly extending multi-portion processing channel defined in said rotor for processing a suspension including at least one cell component, said processing channel being defined by a pair of spaced-apart rigid vertical walls, said channel having a height substantially greater than its width along a substantial length of said channel;
- said processing channel including,
- a first arcuate portion,
- a second portion which is generally spiral-like, and
- a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said first and second portions and defining a generally inwardly extending surface within said channel to restrict the passage of at least one suspension component between said first and second portions.
3 more elements
A centrifuge assembly comprising:
- a rotor;
- means providing a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component;
- extracting a portion of said suspension from said channel at a third location which is spaced from said first and second locations.
A process for separating a suspension component from a suspension containing a cell component comprising:
- providing a centrifuge assembly comprising a rotor having a generally annularly extending multi-portion processing channel defined therein, said channel having one portion for performing a separation function and another portion which is generally spiral-like relative to the true center of the rotor for performing another separation function;
- introducing said suspension into the processing channel at a first location and passing the suspension or component thereof through at least a part of said one and said other portions of said channel;
- rotating the centrifuge assembly to separate a first suspension component in the suspension;
- and
- extracting said first suspension component from said other, spiral-like portion of said channel at a second location that is at a greater radial distance from the true center of said rotor than the radial distance where said first suspension component enters said spiral-like portion of said channel and is spaced from said first location.
2 more elements
Dependencies are inferred from the claim text.