Complex for in-vivo target localization

A macro-molecular complex for target localization comprising:

• an albumin central core having a surface thereof;
• a polysaccharide spacer arm coupled to the central core;
• and
• an antibody molecule coupled to the spacer arm;
• wherein the polysaccharide spacer arm comprises five monosaccharides to twenty-four thousand monosaccharides and wherein said polysaccharide is coupled to the surface of said central core such that said polysaccharide is not incorporated into said central core, said polysaccharide thereby being oriented so that the antibody molecule has translational freedom and reduced steric hindrance when coupled to the polysaccharide spacer arm.

A process for producing a macro-molecular complex with a central core coupled to a polysaccharide spacer arm that is coupled to a specific targeting molecule comprising:

• forming a bio-compatible central core suitable for in-vivo circulation;
• coupling a polysaccharide spacer arm to the central core;
• and
• coupling the spacer arm to a specific targeting molecule;
• wherein the polysaccharide spacer arm comprises five monosaccharides to twenty-four thousand monosaccharides.

A process for producing a macro-molecular complex with a central core coupled to a polysaccharide spacer arm that is coupled to a specific targeting molecular comprising:

• heat stabilizing albumin to form microspheric central cores suitable for in-vivo use;
• coupling a polysaccharide spacer arm to the albumin central core;
• and
• coupling the spacer arm to an antibody molecule;
• wherein the polysaccharide spacer arm comprises five monosaccharides to twenty-four thousand monosaccharides.

A macro-molecular complex for target localization produced by:

• forming a bio-compatible central core suitable for in-vivo circulation;
• coupling a polysaccharide spacer arm to the central core;
• and
• coupling the spacer arm to a specific targeting molecule;
• wherein said polysaccharide spacer arm comprises five monosaccharides to twenty-four thousand monosaccharides.