Substituted cyclic tetrapeptides
AssigneeG. D. Searle & Co.
InventorsDonald W. Hansen, Jr., Karen B. Peterson, Nizal S. Chandrakumar, Henry I. Mosberg
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Abstract
The present invention provides substituted cyclic tetrapeptide compounds of Formula I: ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, which are useful for treating pain in animals, pharmaceutical compositions which comprises a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Claims29
A compound having the structure:
- ##STR93## and the pharmaceutically-acceptable salts, esters and amides thereof, wherein:
- A is:
- hydrogen, ##STR94## Z is:
- sulfur, nitrogen or oxygen;
- X is:
- hydrogen, halogen, nitro, lower alkyl, lower alkyl substituted by halogen or nitro, aralkyl, alkaryl, or aralkyl or alkaryl substituted by hydrogen, halogen, nitro, lower alkyl or lower alkyl substituted by halogen or nitro;
- R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, R.sup.9 and R.sup.10 are:
- independently hydrogen or alkyl, with the proviso that R.sup.6, R.sup.7, R.sup.9 and R.sup.10 are not each hydrogen;
- R.sup.5 is:
- amino, hydroxy, alkoxy, alkylamino, dialkylamino or alkoxyaryl;
- R.sup.8 is:
- hydrogen, alkyl, alkyl carbonyl, alkoxy carbonyl, amino carbonyl, alkylaminocarbonyl or dialkylamino carbonyl, with any of the foregoing R.sup.8 substituents being aryl substituted;
- and
- m and n are:
- each independently an integer of from 0 to 4.
Dependencies are inferred from the claim text.