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US 5,216,115 AGranted
Polyarylate containing derivatives of the natural amino acid L-tyrosine
AssigneeRutgers, The State University of New Jersey
InventorsJoachim B. Kohn, James J. Fiordeliso
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Abstract
Bioerodible polyarylates derived from biocompatible dicarboxylic acids and natural amino acid-derived diphenol starting materials. Molded articles and controlled drug delivery systems prepared from the polyarylates are also disclosed.
Claims15
An amino acid-derived polyarylate comprised of one or more recurring structural units represented by the formula:
- ##STR11## wherein X is selected from the group consisting of --H, --NHL.sub.1, --NL.sub.1 L.sub.2,:
- ##STR12## Y is hydrogen or an ester group having the structure:
- ##STR13## wherein L.sub.1, L.sub.2 and L.sub.3 are independently selected from the group consisting of straight or branched alkyl and alkylaryl groups containing up to 18 carbon atoms and a biologically or pharmacologically active ligand;
- and
- R is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms.
2 more elements
Dependencies are inferred from the claim text.