Cell growth inhibitors and methods of treating cancer and cell proliferative diseases
AssigneeBaylor College of Medicine
InventorsBarry M. Markaverich, James H. Clark, Rebecca Gregory, Mary Alejandro, Brian S. Middleditch, Gregory A. Johnson, Rajender S. Varma
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Abstract
The present invention discloses new and useful compounds including methyl p-hydroxyphenyllactate, its analogues, chemical derivatives and chemically related compounds and their use as antitumor agents, as inhibitors of proliferative cell growth and as prophylactic agents to inhibit and prevent cancer and non-malignant cell growth.
Claims78
A method of regulating cell growth and proliferation in normal and malignant cells, comprising the step of administering, to an individual in need of said treatment, a therapeutic dose of a compound selected from the group consisting of the formulae:
- ##STR10## wherein, R.sub.1 is selected from the group consisting of H, alkyl groups containing 1 to 6 carbons and aryl groups;
- R.sub.2 and R.sub.3 are not both H and are selected from the group consisting of H, OH and OCH.sub.3 ;
- and
- R.sub.4 is selected from the group consisting of H and an alkyl group of 1 to 6 carbons.
A method of inhibiting the growth of proliferating cells which include a Type II nuclear estrogen binding site comprising the step of administering, to the proliferating cells, a biologically inhibiting dose of a compound selected from the group consisting of the formulae:
- ##STR11## wherein R.sub.1 is selected from the group consisting of H, alkyl group containing 1 to 6 carbons and aryl groups;
- R.sub.2 and R.sub.3 are not both H and are selected from the group consisting of H, OH and OCH.sub.3 ;
- and
- R.sub.4 is selected from the group consisting of H and an alkyl group of 1 to 6 carbons.
A method for treating benign prostatic hyperplasia, comprising the step of administering a therapeutic dose of a compound selected from the group consisting of the formulae:
- ##STR12## wherein, R.sub.1 is selected from the group consisting of H, alkyl groups containing 1 to 6 carbons and aryl groups;
- R.sub.2 and R.sub.3 are not both H and are selected from the group consisting of H, OH and OCH.sub.3 ;
- and
- R.sub.4 is selected from the group consisting of H and an alkyl group of 1 to 6 carbons.
As an agent for regulating cell growth and proliferation in normal and malignant cells, a compound selected from the group consisting of the formulae:
- ##STR13## wherein, R.sub.1 is selected from the group consisting of H, alkyl groups containing 1 to 6 carbons and aryl groups;
- R.sub.2 and R.sub.3 are not both H and are selected from the group consisting of H, OH and OCH.sub.3 ;
- and
- R.sub.4 is selected from the group consisting of H and an alkyl group of 1 to 6 carbons.
A method for inhibiting the growth of proliferating cells comprising administration of a biologically inhibiting dose of a compound selected from the group consisting of:
- ##STR14## and pharmaceutically acceptable salts thereof, wherein, R.sub.1 is selected from the group consisting of H, alkyl groups containing 1 to 6 carbons, and substituted or unsubstituted aryl groups;
- and
- R.sub.2 and R.sub.3 are not both H and are selected from the group consisting of H, OH and OCH.sub.3.
A method of treating benign prostatic hyperplasia, comprising the administration of a therapeutic dose of a compound selected from the group consisting of:
- ##STR16## and pharmaceutically acceptable salts thereof, wherein, R.sub.1 is selected from the group consisting of H, alkyl groups containing 1 to 6 carbons, and substituted and unsubstituted aryl groups;
- and
- R.sub.2 and R.sub.3 are not both H and are selected from the group consisting of H, OH and OCH.sub.3.
Dependencies are inferred from the claim text.