Controlled release matrix suppository for pharmaceuticals
AssigneeEuroceltique, S.A.
InventorThinnayam N. Krishnamurthy
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Abstract
The controlled release of therapeutically active agents is achieved from a controlled release matrix of sodium alginate and a calcium salt. When the composition is to be administered rectally, the matrix is combined with a therapeutically active agent and a suitable suppository base. When the composition is to be administered orally, the matrix further includes a higher aliphatic alcohol.
Claims13
A controlled release pharmaceutical suppository for rectal administration in humans or animals, comprising
- a controlled release matrix consisting essentially of a pharmaceutically acceptable sodium alginate and a pharmaceutically acceptable calcium salt selected from the group consisting of calcium phosphate, dicalcium phosphate, calcium chloride, calcium carbonate, calcium acetate, calcium gluconate, and mixtures of any of the foregoing,
- a therapeutically active agent, and
- a suitable vehicle which melts or dissolves in rectal fluids, said calcium salt being in an amount sufficient to cross-link with the sodium alginate and thereby provide a controlled release of said therapeutically active agent from said matrix when said vehicle melts or dissolves.
A method for providing a controlled release suppository containing a pharmaceutically active agent for rectal administration in humans and animals, comprising
- combining a controlled release matrix consisting essentially of a pharmaceutically acceptable sodium alginate and a pharmaceutically acceptable calcium salt selected from the group consisting of calcium phosphate, dicalcium phosphate, calcium chloride, calcium carbonate, calcium acetate, calcium gluconate, and mixtures of any of the foregoing with an affective amount of a therapeutically active agent to provide a therapeutic effect,
- adding the mixture to a sufficient quantity of a suitable melted vehicle and then preparing suppositories, and
- including the calcium salt in an effective amount to cross-link the sodium alginate and thereby provide a controlled release of the therapeutically active agent when said vehicle melts or dissolves.
Dependencies are inferred from the claim text.