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US 5,215,541 AGranted
Surfactant treatment of implantable biological tissue to inhibit calcification
AssigneeBaxter International Inc.
InventorsAws S. Nashef, Ahmed I. Ahmed
Life of this patent
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Abstract
A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the treatment of tissue with an effective amount of a surfactant to reduce calcification of the implanted tissue.
Claims12
A method for reducing calcification of biological tissue after implantation in an animal comprising:
- fixing the biological tissue under tissue fixing conditions;
- and
- contacting the biological tissue with a solution of an anionic surfactant prior to implantation in an amount effective in reducing calcification of the tissue after implantation;
- wherein the surfactant is selected from the group consisting of ethylene oxide sulfates of aliphatic alcohols, sulfates of alkylphenols, alkane sulfonic acids, alkylaryl sulfonic acids, salts of bile acids, salts of fatty acids, N-alkanoyl amino acids, N-acylated amino acids, sulfated ethanol amides, sulfated alkylphenol ethers, and salts thereof.
1 more element
Dependencies are inferred from the claim text.