Method for making a capsule-shaped tablet
AssigneeL. Perrigo Company
InventorsDouglas B. Hampton, George W. Tilton, Maureen L. Jordan
Life of this patent
Estimating the term…
Abstract
A method for making a multi-characteristic, bi-layer, capsule-shaped tablet by filling a die with a blend of one or more excipients and one or more active substances, including a first distinguishing ingredient, e.g., a first coloring agent, leveling the first blend and cleaning the die walls above the first blend, adding a second blend including a second distinguishing ingredient, e.g., a second coloring agent, and compressing both blends longitudinally in the die into the shape of a two component capsule. The tablet is coated with a clear coating, such as gelatin, to provide a solid medicament with the appearance of a gelatin capsule.
Claims44
A method of manufacturing a pharmaceutical tablet comprising:
- filling a die cavity partially with a first blend of solid particulate excipients and active substances, and a first coloring agent;
- leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend;
- filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, and a second coloring agent;
- compressing said first blend and said second blend along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet;
- and
- removing the capsule-shaped tablet from the die cavity.
A method of manufacturing a pharmaceutical tablet comprising:
- filling a die cavity partially with a first blend of solid particulate excipients and active substances, and a first coloring agent;
- rotating the die cavity on a rotary press;
- leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend;
- rotating said die cavity on said rotary press;
- filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, and a second coloring agent;
- rotating said die cavity on said rotary press;
- compressing said first blend and said second blend between a lower punch and an upper punch along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet;
- rotating said die cavity on said rotary press;
- and
- ejecting the layered capsule-shaped tablet from the rotary press.
A method of manufacturing a pharmaceutical tablet comprising:
- filling a die cavity partially with a first blend of solid particulate excipients and active substances, including a first distinguishing ingredient;
- leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend;
- filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, including a second distinguishing ingredient;
- compressing said first blend and said second blend along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet;
- and
- removing the capsule-shaped tablet from the die cavity.
A method of manufacturing a pharmaceutical tablet comprising:
- filling a die cavity partially with a first blend of solid particulate excipients and active substances, including a first distinguishing ingredient;
- rotating the die cavity on a rotary press;
- leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend;
- rotating said die cavity on said rotary press;
- filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, including a second distinguishing ingredient;
- rotating said die cavity on said rotary press;
- compressing said first blend and said second blend between a lower punch and an upper punch along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet;
- rotating said die cavity on said rotary press;
- and
- ejecting the layered capsule-shaped tablet from the rotary press.
A method of manufacturing a pharmaceutical tablet comprising:
- filling a die cavity partially with a first blend of solid particulate excipients and active substances, including a first distinguishing ingredient;
- leveling said first blend in said die cavity;
- filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, including a second distinguishing ingredient;
- compressing said first blend and said second blend along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet;
- and
- removing the capsule-shaped tablet from the die cavity.
Dependencies are inferred from the claim text.