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US 5,212,324 AGranted
Treatment of cataract with 15-keto-prostaglandin compounds
AssigneeR-Tech Ueno, Ltd.
InventorRyuji Ueno
Life of this patent
Estimating the term…
Abstract
A compound for treatment of a cataract which is a 15-ketoprostaglandin compound.
Claims14
A compound of the formula:
- ##STR10## wherein each of L and M is hydrogen atom, hydroxy, lower alkyl, hydroxy(lower)alkyl or oxo, provided that at least one of L and M is not hydrogen atom and that the five-membered ring may have one or two double bonds, each of Q.sub.1 and Q.sub.2 is hydrogen atom, halogen atom or lower alkyl, with at least one of Q.sub.1 and Q.sub.2 is a halogen atom or lower alkyl, D is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.dbd.C-- or --CO--CH.sub.2 --, E is --CH.sub.2 --CH.sub.2 --, or --CH.dbd.CH--, W is --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--CH.sub.2 or --CH.sub.2 --CH.dbd.CH--, Ra is hydrogen atom, lower alkyl, lower cycloalkyl, monocyclic aryl, monocyclic aryl(lower)alkyl or monocyclic aroyl(lower)alkyl, Rb is single bond or lower alkylene, Rc is lower alkyl which is unsubstituted or substituted by halogen, lower cycloalkyl which is unsubstituted or substituted by lower alkyl, monocyclic aryl which is unsubstituted or substituted by halogen or halo(lower)alkyl, or monocyclic arloxy which is unsubstituted or substituted by halogen or halo(lower)alkyl.
A compound of the formula:
- ##STR11## wherein each of L and M is hydrogen atom, hydroxy, lower alkyl, hydroxy(lower)alkyl or oxo, provided that at least one of L and M is not hydrogen atom and that the five-membered ring may have one or two double bonds, both of Q.sub.1 and Q.sub.2 are hydrogen atoms and Rb-Rc is C.sub.6 -C.sub.12 alkyl group which is unsubstituted or substituted by halogen, D is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.dbd.C-- or --CO--CH.sub.2 --, E is --CH.sub.2 --CH.sub.2 --, or --CH.dbd.CH--, W is --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--CH.sub.2 or --CH.sub.2 --CH.dbd.CH--, Ra is hydrogen atom, lower alkyl, lower cycloalkyl, monocyclic aryl, monocyclic aryl(lower)alkyl or monocyclic aroyl(lower)alkyl.
A compound according to claim 14, in which E is --CH.sub.2 --CH.sub.2 --.
A compound of the formula:
- ##STR12## wherein each of L and M is hydrogen atom, hydroxy, lower alkyl, hydroxy(lower)alkyl or oxo, provided that at least one of L and M is not hydrogen atom and that the five-membered ring may have one or two double bonds, both of Q.sub.1 and Q.sub.2 are hydrogen atoms and Rb is single bond or lower alkylene, and Rc is lower cyclo alkyl which is unsubstituted or substituted by lower alkyl, monocyclic aryl which is unsubstituted or substituted by halogen or halo(lower)alkyl, or monocyclic aryloxy which is unsubstituted or substituted by halogen or halo(lower)alkyl, D is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.dbd.C-- or --CO--CH.sub.2 --, E is --CH.sub.2 --CH.sub.2 --, or --CH.dbd.CH--, W is --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--CH.sub.2 or --CH.sub.2 --CH.dbd.CH--, Ra is hydrogen atom, lower alkyl, lower cycloalkyl, monocyclic aryl, monocyclic aryl(lower)alkyl or monocyclic aroyl(lower)alkyl.
Dependencies are inferred from the claim text.