Process for producing 6-(3-dimethylaminopropionyl)forskolin

Abstract

Disclosed in a process for producing 6-(3-dimethylaminopropionyl)forskolin, comprising the sequential steps of: (1) acetylating hydroxy groups in the 1-position and 7-position of a compound represented by the formula (III): ##STR1## to prepare 1-acetyl-6-(3-dimethylaminopropionyl)-forskolin represented by the formula (II): ##STR2## (wherein Ac represents acetyl group), and (2) selectively removing the acetyl group in the 1-position of the compound represented by the formula (II) in the presence of an amine represented by the formula (IV): ##STR3## (wherein R.sub.1 represents hydrogen atom or lower alkyl group having 1-6 carbon atoms, and R.sub.2 represents lower alkyl group having 1-6 carbon atoms, alkoxyalkyl group, aminoalkyl group or benzyl group) in a solvent to prepare 6-(3-dimethylaminopropionyl)forskolin represented by the formula (I): ##STR4## (wherein Ac represents the same as defined in the formula (II)). The compound (I) is promising as a therapeutic agent for cardiac failure.

Dependencies are inferred from the claim text.