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US 5,212,311 AGranted
Chiral amino-methyl ferrocene derivatives
AssigneeTosoh Corporation
InventorsMakoto Watanabe, Masaru Uemura, Shuki Araki, Yasuo Butsugan
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Abstract
A ferrocene derivatives represented by the following formula (I): ##STR1## can be a useful ligand to metals with Lewis acidity and is used as a catalyst for asymmetric synthesis with good enantioselectivity. This ferrocene derivatives is synthesized from a novel haloferrocene derivative represented by formula (II) and the haloferrocene derivative is synthesized from a novel ferrocene derivative represented by formula (III).
Claims6
A ferrocene derivative with chirality represented by the following formula (I):
- ##STR58## wherein R.sup.1 represents an alkyl group, R.sup.2 and R.sup.3 respectively represent an alkyl group, an aryl group or a benzyl group, or NR.sup.2 R.sup.3 together form a heterocyclic ring in which R.sup.2 R.sup.3 represents a hydrocarbon chain having 4 to 6 carbon atoms, R.sup.4 and R.sup.5 are the same or different and represent hydrogen, a lower alkyl group having 2 to 6 carbon atoms, an aryl group, an anthracenyl group or a ferrocenyl group, or R.sup.4 and R.sup.5 form a cycloalkyl group having 5 to 7 carbon atoms or a 9-(10-hydroanthracenyl) group together with a carbon atom to which R.sup.4 and R.sup.5 bond, wherein R.sup.4 and R.sup.5 are not hydrogen at the same time, and when R.sup.1, R.sup.2 and R.sup.3 are methyl groups, R.sup.4 and R.sup.5 are not phenyl groups at the same time and are not respectively p-methoxyphenyl and hydrogen.
Dependencies are inferred from the claim text.