Antihypertensive compositions and use thereof
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsLarry K. Keefer, David A. Wink, Tambra M. Dunams, Joseph A. Hrabie
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Abstract
This invention concerns antihypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein J is an organic or inorganic moiety, M.sup.+x is a pharmaceutically acceptable cation and the compound decomposes under physiological conditions to release nitric oxide (NO).
Claims27
An injectable pharmaceutical composition consisting essentially of a compound of the formula ##STR18## wherein J is an inorganic moiety, or an organic moiety selected from the group consisting of C.sub.1 -C.sub.12 aliphatic, C.sub.3 -C.sub.8 cycloalkyl, benzyl, phenyl, substituted benzyl, substituted phenyl, benzycarbonyl, phenylcarbonyl, substituted benzylcarbonyl, substituted phenylcarbonyl, C.sub.1 -C.sub.12 acyl, and ##STR19## wherein R is C.sub.1 -C.sub.12 aliphatic, C.sub.3 -C.sub.8 cycloalkyl, benzyl, phenyl, substituted benzyl or substituted phenyl, and said substituted benzyl and substituted phenyl is substituted with one or two substituents selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, amino, mono C.sub.1 -C.sub.4 alkylamino, di C.sub.1 -C.sub.4 alkyl-amino, phenyl and phenoxy;
- M.sup.+x is a pharmaceutically acceptable cation, wherein x is the valence of the cation, a is 1, b and c are the smallest integers that result in a neutral compound, and wherein the compound decomposes under physiological conditions to release nitric oxide (NO);
- and
- a pharmaceutically acceptable sterile carrier.
An injectable pharmaceutical composition consisting essentially of a compound of the formula ##STR20## wherein J is an inorganic moiety or an organic moiety;
- M.sup.+x is a pharmaceutically acceptacle cation, wherein x is the valence of the cation, a is 2, b and c are the smallest integers that result in a neutral compound, and wherein the compound decomposes under physiological conditions to release nitric oxide (NO);
- and
- a pharmaceutically acceptable sterile carrier.
A method of treating cardiovascular disorders in mammals by lowering the blood pressure comprising:
- administering to a mammal in need thereof a blood pressure lowering effective amount of a compound of the formula ##STR25## wherein J is an organic or inorganic moiety, M.sup.+x is a pharmaceutically acceptable cation, wherein x is the valence of the cation, a is 1 or 2, b and c are the smallest integers that result in a neutral compound, and wherein the compound decomposes under physiological conditions to release nitric oxide (NO).
Dependencies are inferred from the claim text.