Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
AssigneeG. D. Searle & Co.
InventorsStevan W. Djuric, Thomas D. Penning, James P. Snyder
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AssigneeG. D. Searle & Co.
InventorsStevan W. Djuric, Thomas D. Penning, James P. Snyder
Estimating the term…
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or (CH.sub.2).sub.m R.sup.3 where R.sup.3 is cycloalkyl and m is 1 or 2; R.sup.1 is alkyl; R.sup.2 is hydrogen or alkyl; R.sup.4 is alkyl; n is an integer from 1 to 5; p is an integer from 0 to 6; Y is NH, oxygen or sulfur; and Z is hydrogen, alkyl, alkoxy, NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen or alkyl, or SR.sup.6 wherein R.sup.6 is hydrogen, benzyl or alkyl. The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in the treatment of leukotriene B.sub.4 mediated conditions.
A compound of the formula:
Dependencies are inferred from the claim text.