Heterocyclic compounds

A thiazoline derivative of the formula:

• ##STR116## wherein Z represents sulfur atom, R represents the general formula:
• G--E--D--B--A--
• wherein A represents a linkage which contains no atom, alkylene group of from 1 to 6 carbon atom(s), alkenylene group of from 2 to 6 carbon atoms, a group of the formula:
• ##STR117## wherein Y represents alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms, a saturated hydrocarbon ring of from 4 to 7 carbon atoms or heterocyclic mono ring containing 3 to 7 ring members including 1 or 2 hetero atom(s) selected from N, O and S atoms which may be partially or fully saturated or aromatic,
• B represents a linkage which contains no atom or alkylene group of from 1 to 6 carbon atom(s),
• D represents a linkage which contains no atom, oxygen atom, carbonyl group or a group of the formula:
• --NR.sup.1 --CO-- or --CO--NR.sup.1 --
• wherein R.sup.1 represents hydrogen atom, alkyl group of from 1 to 6 carbon atom(s), phenyl group or benzyl group,
• E represents a linkage which contains no atom, alkylene group of from 1 to 8 carbon atom(s) or alkylene group of from 1 to 8 carbon atom(s) substituted by phenyl or benzyl group,
• G represents a mono-, bi- or tri-carbocyclic ring(s) containing not more than 15 carbon atoms which may be partially or fully or saturated or aromatic, or mono-, bi- or tri-heterocyclic ring(s) containing not more than 15 ring members including carbon and 1 or 2 hetero atoms selected from N, O and S atoms which may be partially or fully saturated or aromatic wherein said carbocyclic or heterocyclic ring(s) represented by G is unsubstituted or substituted by 1-3 of alkyl group of from 1 to 6 carbon atom(s), alkoxy group of from 1 to 6 carbon atom(s), halogen atom, trifluoromethyl group or nitro group,
• L represents a group of the formula:
• ##STR118## wherein R.sup.3 represents alkyl group of from 1 to 6 carbon atom(s), phenyl group, or alkyl group of from 1 to 6 carbon atom(s) substituted by phenyl group,
• with the proviso that the following compounds are excluded:
• (i) compounds wherein both of A and B are linkage which contains no atom
• or non-toxic salt or hydrate thereof.