Thiadiazole or oxadiazole analogs of fenamic acids containing substituted hydroxamate side chains as antiinflammatory agents
AssigneeWarner-Lambert Company
InventorsThomas R. Belliotti, David T. Connor, Catherine R. Kostlan
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Abstract
The present invention is a novel compound which is a thiadiazole or oxadiazole analog of a fenamic acid having a substituted hydroxamate side chain and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of one or both of cyclooxygenase and 5-lipoxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like. Thus, the present invention is also a pharmaceutical composition or method of use thereof.
Claims23
A compound of the Formula (I) ##STR11## or a pharmaceutically acceptable salt thereof;
- wherein Q is S or O;
- R.sub.10 is --OH, --SH, or --NH.sub.2 ;
- R.sub.1 is H or lower alkyl;
- X is H, halogen, lower alkyl, lower alkoxy, CF.sub.3, or OH;
- Y is H, halogen, lower alkyl, lower alkoxy, CF.sub.3, or OH;
- ##STR12## wherein W is S or O,
- Z is lower alkyl, lower alkoxy, NR.sub.2 R.sub.3
- wherein R.sub.2 and R.sub.3 are independently H or lower alkyl.
Dependencies are inferred from the claim text.