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US 5,212,187 AGranted
Pyridyl alkylamine compounds which are useful against histamine H.sub.1 and H.sub.2 receptors
AssigneeZyma SA
InventorsRudi A. Alisch, Frank R. Schulze, Armin Buschauer, Walter Schunack
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Abstract
Arylalkylamine derivatives of the general formula ##STR1## are described which, owing to their anatagonistic action against histamine H.sub.1 - and H.sub.2 -receptors, can be used for the prophylaxis and treatment of disorders in which histamine is involved. They are prepared in a manner known per se.
Claims10
An arylalkylamine derivative of the formula (I) ##STR15## wherein R.sub.1 is phenyl which is unsubstituted or mono- or di-substituted by at least one member selected from the group consisting of halogen, C.sub.1 -C.sub.3 alkyl and C.sub.1 -C.sub.3 alkoxy,
- A is CH,
- E is --(CH.sub.2).sub.p --, --O--(CH.sub.2).sub.p -- or --S--(CH.sub.2).sub.p -- wherein p is 2, 3 or 4,
- Q is a nitrogen atom,
- R.sub.2 is a member selected from the group consisting of piperidino-C.sub.1 -C.sub.3 alkyl-phenyl, guanidine-thiazolyl-C.sub.1 -C.sub.3 alkyl and (N,N-di-C.sub.1 -C.sub.3 alkylamino-C.sub.1 -C.sub.3 alkyl)-furanyl-C.sub.1 -C.sub.3 alkyl,
- R.sub.3 is hydrogen or C.sub.1 -C.sub.3 alkyl,
- X is oxygen or sulfur,
- m is 2, 3, 4, 5, 6, 7 or 8,
- n is 1, 2, 3 or 4, and
- Y is sulfur or oxygen,
- or a stereoisomeric form, a hydrate or a physiologically acceptable said thereof.
7 more elements
Dependencies are inferred from the claim text.