Piperidine derivatives

A method for alleviating depression in a mammal afflicted with depression, which comprises administering to said mammal an amount effective to alleviate depression of a compound of the formula ##STR23## wherein n is 0 or 1;

• R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1 -C.sub.4 alkyl;
• X is .dbd.O or .dbd.S;
• Y is --O-- or a direct bond;
• Z is --CO-- or --CH.sub.2 --;
• R is phenyl or phenyl substituted by one or two substituents selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, fluoro, chloro, bromo, chloroethyl, trifluoromethyl, and nitro, and;
• Ar is 2, 4, 5 or 6-quinolinyl or 2, 4, 5 or 6-quinolinyl substituted by one or two substituents selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, fluoro, chloro, bromo, chloroethyl, trifluoromethyl, amino, C.sub.1 -C.sub.4 alkylamino, di-(C.sub.1 -C.sub.4 alkyl)amino, C.sub.1 -C.sub.4 alkylcarbonylamino, dimethane or diethanesulphonylamino, nitro or cyano, or
• a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof, in which the dotted line represents an optional double bond.

A compound of the formula ##STR24## wherein n is 0 or 1;

• R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1 -C.sub.4 alkyl;
• X is .dbd.O or .dbd.S;
• Y is --O-- or a direct bond;
• Z is --CO-- or --CH.sub.2 --;
• R is phenyl or phenyl substituted by one or two substituents selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, fluoro, chloro, bromo, chloroethyl, trifluoromethyl, and nitro, and;
• Ar is 3, 4, 5 or 6-isoquinolinyl or 3, 4, 5 or 6-isoquinolinyl substituted by one or two substituents selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, fluoro, chloro, bromo, chloroethyl, trifluoromethyl, amino, C.sub.1 -C.sub.4 alkylamino, di-(C.sub.1 -C.sub.4 alkyl)amino, C.sub.1 -C.sub.4 alkylcarbonylamino, dimethane or diethanesulphonylamino, nitro or cyano, or
• a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof, in which the dotted line represents an optional double bond.

A method for alleviating depression in a mammal afflicted with depression, which comprises administering to said mammal an amount effective to alleviate depression of a compound of the formula ##STR25## wherein n is 0 or 1;

• R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1 -C.sub.4 alkyl;
• X is .dbd.O or .dbd.S;
• Y is --O-- or a direct bond;
• Z is --CO-- or --CH.sub.2 --;
• R is phenyl or phenyl substituted by one or two substituents selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, fluoro, chloro, bromo, chloroethyl, trifluoromethyl, and nitro, and;
• Ar is 3, 4, 5 or 6-isoquinolinyl or 3, 4, 5 and 6-isoquinolinyl substituted by one or two substituents selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, fluoro, chloro, bromo, chloroethyl, trifluoromethyl, amino, C.sub.1 -C.sub.4 alkylamino, di-(C.sub.1 -C.sub.4 alkyl)amino, C.sub.1 -C.sub.4 alkylcarbonylamino, dimethane or diethanesulphonylamino, nitro or cyano, or
• a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof, in which the dotted line represents an optional double bond.